Pyruvate improves myocardial functional recovery after ischemia and reperfusion

by Mehrdad Yazdanpanah

Publisher: National Library of Canada in Ottawa

Written in English
Published: Downloads: 727
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Edition Notes

Thesis (M.Sc.) -- University of Toronto, 1997.

SeriesCanadian theses = -- Thèses canadiennes
The Physical Object
FormatMicroform
Pagination1 microfiche : negative. --
ID Numbers
Open LibraryOL18812181M
ISBN 100612340783
OCLC/WorldCa46580841

Coenzyme Q is LIKELY SAFE for most adults when taken by mouth or when applied directly to the gums. While most people tolerate coenzyme Q well, it can cause some mild side effects including stomach upset, loss of appetite, nausea, vomiting, and can cause allergic skin rashes in some people. It also might lower blood pressure, so check your blood pressure carefully if you have.   Kennedy JA, Kiosoglus AJ, Murphy GA, et al. Effect of perhexilline and oxfenicine on myocardial function and metabolism during low flow ischemia/reperfusion in the isolated rat heart. J Cardiovasc Pharmacol ; –Author: Gabriele Fragasso. This collection includes theses and dissertations from the Department of Physiology and Biophysics, in the School of Medicine. It is not exhaustive since most paper theses and dissertations have not been digitized. Generally, paper copies of theses and dissertations published prior to can be accessed in the University of Louisville Libraries. of the heart to ischemia and reperfusion (Hansford, Naotaka & Pepe, ). The propensity for ROS/RNS emissions increases with omega-3 supplementation, although there are no changes in markers of lipid or protein oxidative damage. These results demonstrate that omega-3 supplementation improves mitochondrial ADP kinetics.

Achievements Continuing education a.o. qualification upgrade. Visit to University of Antwerp (Belgium), March Field of research. Drug discovery, pharmacology, molecular mechanisms and medicinal chemistry related to the anti-ischemic drugs with novel mechanisms of action; cognition, cellular energy metabolism, and inflammation. 93 publications, H-index 15 (Scopus), 25 international. WOA1 PCT/IB/ IBW WOA1 WO A1 WO A1 WO A1 IB W IB W IB W WO A1 WO A1 WO A1 Authority WO WIPO (PCT) Prior art keywords dca inotrope patients kg bolus Prior art date Application number PCT/IB/ Cited by: 1.   Treatment of acute cerebral ischemia using animal models: a meta-analysis E., Castagne V., Moser P., Bonny C., Bernalidin M., D-JNKi, a peptide inhibitor of c-Jun N-terminal kinase, promotes functional recovery after transient focal characterization and protective effects on global cerebral ischemia/reperfusion injury and acute Author: Peng-Fei Wang, Yu Zhou, Huang Fang, Sen Lin, Yan-Chun Wang, Yong Liu, Jun Xia, Guy D. Eslick, Qing-W.   Introduction. Resuscitative endovascular balloon occlusion of the aorta (REBOA) is an endovascular hemorrhage control intervention that was first described in the Korean war ().REBOA has recently re-gained popularity as an alternative to resuscitative thoracotomy (RT, thoracotomy and aortic cross-clamping) in trauma patients (2–8).RT has been associated with low survival rates (9, 10) and Author: Guillaume L. Hoareau, Emily M. Tibbits, Emily M. Tibbits, Carl A. Beyer, Carl A. Beyer, Meryl A. Sim.

Further support for dopaminergic activity in restoring functional recovery after TBI comes from a preclinical study showing that selegiline (L-deprenyl), which enhances the action of DA by inhibiting its main catabolic enzyme in brain, monoamine oxidase-B, improved cognitive outcome when given daily for 7 days after fluid percussion injury. TRANSFER OF ENERGY, THE PRIME MOVER OF METABOLISM. As stated, the key function of intermediary metabolism is the regulated, controlled transfer of chemical energy to adenosine triphosphate (ATP) and, by implication, to contraction of the heart muscle ().This is a complex process, the details of which were discovered over a period of many years, and includes 3 phases: pathway . Interestingly, in both models, deletion or inhibition of cardiac MCD improves functional recovery after ischemia (49, 50). In addition, reducing MCD expression in myocytes by small interfering MCD RNA expression increased malonyl-CoA concentration, decreased palmitate oxidation, and increased glucose uptake without affecting insulin signaling Cited by: Schurr A, Payne RS, Miller JJ, Rigor BM () Brain lactate is an obligatory aerobic energy substrate for functional recovery after hypoxia: further in vitro validation. J Neurochem 69(1): Rice AC, Zsoldos R, Chen T, Wilson MS, Alessandri B, et al. () Lactate administration attenuates cognitive deficits following traumatic brain Author: Runkuan Yang, Tor Inge Tonnessen, Sujun Li, Jyrki Tenhunen.

Pyruvate improves myocardial functional recovery after ischemia and reperfusion by Mehrdad Yazdanpanah Download PDF EPUB FB2

This phenomenon of tissue damage and even irreversible damage after ischemic myocardial blood flow recovery is called myocardial ischemia-reperfusion injury (MIRI) [3] [4]. MIRI is the most common. Ethyl pyruvate preserves cardiac function and attenuates oxidative injury after prolonged myocardial ischemia Article in Journal of Thoracic and Cardiovascular Surgery (5) June @article{osti_, title = {TRIIODOTHYRONINE INCREASES MYOCARDIAL FUNCTION AND PYRUVATE ENTRY INTO THE CITRIC ACID CYCLE AFTER REPERFUSION IN A MODEL OF INFANT CARDIOPULMONARY BYPASS}, author = {Olson, Aaron and Bouchard, Bertrand and Ning, Xue-Han and Isern, Nancy G and Des Rosiers, Christine and Portman, Michael A}, abstractNote = {We utilized.

Inhibition of aldose reductase or sorbitol dehydrogenase reduced ischemic injury, improved functional recovery and ATP levels after ischemia – reperfusion in diabetic rat hearts.

These data suggest that inhibition of polyol pathway could in principle be used as a therapeutic adjunct for protecting ischemic myocardium in type 2 diabetic by: Wang P, Lloyd SG, Chatham JC.

Impact of high glucose/high insulin and dichloroacetate treatment on carbohydrate oxidation and functional recovery after low-flow ischemia and reperfusion in the isolated rat heart.

Circulation. ;–Cited by: 3. Conditions during reperfusion after ischemia are optimal for inducing this transition and thus may play a critical role in determining whether the cell recovers. From an understanding of the properties and mechanism of the MPTP, one can devise perfusion protocols that minimize pore opening and improve heart recovery following by: 1.

Furthermore, the events occurring after ischemia (reperfusion) have been extensively studied, particularly how they impact on early and late metabolic functional recovery. Reperfusion injury Restoration of blood flow to the ischemic myocardium should be expected to reactivate ATP generation for the repair of ischemic injury and the return of.

Proteins of the mitochondrial electron transport chain and oxidative phosphorylation are among the primary targets of ischemia and oxidative stress during reperfusion [].Decreases in activities of adenine nucleotide translocase (ANT) and ATP synthase are among the earliest events after the onset of cardiac ischemia [4, 5, 6, 7].Inhibition of NADH:ubiquinone dehydrogenase (complex I) and Author: Grażyna Nowak.

Abstract. Changes in cellular cation homeostasis figure prominently in the pathogenesis of cellular damage during ischemia and reperfusion. With respect to the functional alterations related to reperfusion of the ischemic heart, it is now recognized that reactivation of the Na +-H + exchange (NHE) following ischemia-induced acidosis plays a key role in the development of such : Danielle Feuvray.

From bedside to bench: ischemia–reperfusion injury in the heart. Ischemia refers to the reduction of blood flow in a given tissue or organ. In the heart, this commonly occurs as a result of an obstruction of the vessels primarily involved in myocardial perfusion – the coronary by: 1.

Impact of high glucose/high insulin and dichloroacetate treatment on carbohydrate oxidation and functional recovery after low-flow ischemia and reperfusion in the isolated rat heart.

In vivo regulation of lipolysis in humans. ().Author: C. Zuurbier and H. Van Wezel. Hearts isolated from BBZ rats, after 12 weeks or 48 weeks diabetes duration, and their non-diabetic littermates, were subjected to IR protocol.

Myocardial function, substrate flux via AR and SDH, and tissue lactate:pyruvate (L/P) ratio (a measure of cytosolic NADH/NAD +), and lactate dehydrogenase (LDH) release (a marker of IR injury) were. When added to the reperfusate after up to 30 minutes of no-flow, global ischemia, however, the drug significantly improves the rate and left ventricular recovery (Fig.

4),45, In contrast, addi- tion of DCA to the perfusate before or during the peri- od of ischemia does not increase cardiac work during recovery This may Cited by:   Inhibition of aldose reductase or sorbitol dehydrogenase reduced ischemic injury, improved functional recovery and ATP levels after ischemia – reperfusion in diabetic rat hearts.

These data suggest that inhibition of polyol pathway could in principle be used as a therapeutic adjunct for protecting ischemic myocardium in type 2 diabetic by: We investigated the efficacy of Ligusticum wallichi aqueous extract (LWE) for myocardial protection against ischemia-reperfusion injury.

Rats were fed for five weeks with either a control diet (sham and ischemia reperfusion (IR) model control groups) or a diet mixed with %, % or % Ligusticum wallichi extract. At the end of the five week period, hearts were excised and subjected to Cited by: Mitochondria are major determinants of cell fate in ischemia/reperfusion injury (IR) and common effectors of cardio-protective strategies in cardiac ischemic disease.

Thyroid hormone homeostasis critically affects mitochondrial function and energy production. Since a low T3 state (LT3S) is frequently observed in the post infarction setting, the study was aimed to investigate the relationship Cited by: Impact of high glucose/high insulin and dichloroacetate treatment on carbohydrate oxidation and functional recovery after low-flow ischemia and reperfusion in the isolated perfused rat heart.

Circulation. Substrate switching can be pharmacologically induced and has been shown to reduce ischemia/reperfusion injury, increase recovery of function after ischemia [61,62] and may even delay the onset of contractile dysfunction during the development of heart failure.

The shift in substrate oxidation towards glucose is associated with more efficient Cited by:   Measurement of Cardiac Function. After stabilization, functional parameters were measured online and continuously in the ex vivo heart; these included heart rate (HR), systolic left ventricular pressure (LVP) and diastolic pressure (diaLVP), and coronary flow (CF).

A saline-filled balloon connected to a catheter was placed in the left ventricle through an opening in the left atrium, with Cited by: 3. Extracorporeal membrane oxygenation (ECMO) provides a bridge to recovery after myocardial injury in infants and children, yet morbidity and mortality remain high.

Weaning from the circuit requires adequate cardiac contractile function, which can be impaired by metabolic disturbances induced either. 1. Introduction. Cardiovascular disease (CVD) is a major health problem worldwide, and it is predicted to be the number one killer by 1 The underlying cause for the majority living with CVD is a diminished oxygen supply to the cardiac muscle, termed ‘ischaemic heart disease’.

Fortunately, epidemiological studies and randomized clinical trials have provided compelling evidence that Cited by:   The beneficial effect of TMZ as an anti-anginal drug was established before it was discovered that the drug acts via partial inhibition of myocardial fatty acid oxidation.

17,30,31 Initial preclinical studies demonstrated that it was cytoprotective in several models of myocardial ischaemia and reperfusion. 32 Kantor et al. have shown that TMZ Author: Giacinta Guarini, Alda Huqi, Doralisa Morrone, Paola Francesca Giuseppina Capozza, Mario Marzilli.

Year book of intensive care and emergency medicine J.V. PW: Lactate-a signal coordinating cell and systemic function.

Rigor BM: Brain lactate is an obligatory aerobic energy substrate for functional recovery after hypoxia: further in vitro validation.

Irisin improves post-ischemic ventricular functional recovery Fig: The effects of irisin on ventricular function in post-ischemic hearts. (C) Representative left ventricular pressure records in experimental hearts subjected to I/R Irisin reduces infarction size of hearts after I/R Fig: Irisin treatment reduced myocardial infarct size.

Brain metabolism involves both the production and the utilization of energy; catabolism is the breakdown and anabolism is the synthesis of components and molecules in the cells.

For energy formation the main catabolic process is the breakdown of glucose with the ultimate formation of high-energy phosphate in the form of adenosine triphosphate (ATP).

Molecular mechanisms of ischemia-reperfusion injury in brain: Ruiz-Navarro, S, et al. Reversible myocardial dysfunction after cardiopulmonary resuscitation. Mild hypothermia improves recovery of cortical extracellular potassium ion activity and excitability after middle cerebral artery occlusion in the rat.

Core tip: Cardiac arrest remains a leading cause of death worldwide, despite tremendous improvements in emergency medical care and increased public delivery of bystander cardiopulmonary resuscitation (CPR).

But progress is being achieved, thanks to the joint efforts of biomedical scientists, physicians and emergency medical personnel to translate laboratory discoveries to the ambulance and Cited by:   Myocardial ischemia is the main cause of death in the Western societies.

Therapeutic strategies aimed to protect the ischemic myocardium have been extensively studied. Reperfusion is the definitive treatment for acute coronary syndromes, especially acute myocardial infarction; however, reperfusion has the potential to exacerbate tissue injury, a process termed reperfusion injury.

Ischemia. Cardioprotection is a common goal of new therapeutic strategies in patients with coronary artery disease and/or left ventricular dysfunction. Myocardial damage following ischaemia/reperfusion injury lead to left ventricular adverse remodelling through many mechanisms arising from different cell types in different myocardial districts, namely the border and remote by: 1.

Post-cardiac arrest syndrome (PCAS) incorporates post-cardiac arrest brain injury, post-cardiac arrest myocardial dysfunction, systemic ischemia/reperfusion syndrome and the precipitating pathology. Brain injury remains the leading cause of death in the post-cardiac arrest period.

One of our main goals during post-resuscitation care is to guide a proper neuroprotective by: 1. Absence of heme oxygenase-1 exacerbates myocardial ischemia/reperfusion injury in diabetic mice. Diabetes. ; – Crossref Medline Google Scholar; Ma J, Lau CK, Obed A, Dada A, Doenecke A, Fan ST, Schlitt HJ, Tsui TY.

A cell penetrating heme oxygenase protein protects heart graft against ischemia/reperfusion injury. Gene by:   It is a purine nucleoside analog that raises adenosine tissue levels selectively during ischemic conditions Early preclinical studies have indicated that acadesine treatment: (1) improves left ventricular wall motion after intermittent ischemia (2) attenuates frequency of ventricular arrhythmias (3) attenuates myocardial stunning and preserves.Heart failure is currently one of the leading causes of death and disability worldwide, which makes it a major public health problem.

1,2 Traditionally, heart failure is considered a complex syndrome with several features, including abnormal myocardial function and excessive, continuous neurohumoral activation. In this context, the current optimal pharmacological treatment of heart failure Cited by: 3.